ABSTRACT
Sickle cell anaemia is an inherited disorder of haemoglobin characterized by sickled red blood cells and increased destruction of these cells. Antioxidants protect cells from the damaging effects of free radicals. The aim of this study was to determine antioxidant vitamin A in steady state sickle cell anaemia patients and that of controls in Maiduguri, Borno state North-Eastern Nigeria. The study was carried out at UMTH Maiduguri. Sixty sickle cell anaemia patients were compared with sixty controls, aged ranged 1 year 3 months to 33 years of age, using HPLC for vitamin A status. The mean vitamin A in sickle cell patients according to age ranged between 0.047±0.002 to 0.053±0.002 mg/ml, while that of controls is 0.053± 0.001 to 0.091±0.001 mg/ml. The maximum mean serum vitamin A (0.053±0.001 mg/ml), in SCA was found in the business and children groups while the minimum vitamin A (0.039±0.001 mg/ml) was recorded in the un-employed SCA patients. The study showed the antioxidant vitamin A was found to be lower in the SCA subjects than in normal control in all age groups. Level of education also plays a role in the level of antioxidant vitamins in the blood.